KCNT2 antibody (PE)

Catalog No. ABIN1430095

This Rabbit Polyclonal antibody specifically detects KCNT2 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KCNT2 antibody (PE) (ABIN1430095)

Target: KCNT2 (Potassium Channel, Subfamily T, Member 2 (KCNT2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNT2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-KCNT2 Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KCNT2

Isotype: IgG

Application Details

Application Notes: FCM(1:20-100)

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for KCNT2

Target: KCNT2 (Potassium Channel, Subfamily T, Member 2 (KCNT2))

Alternative Name: Kcnt2

Background:

Voltage-gated K+ channels in the plasma membrane are important regulators of electrical signaling, controlling the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNT2 is a 1,135 amino acid multi-pass transmembrane protein belonging to the potassium channel family (calcium-activated subfamily) of proteins. KCNT2 produces rapidly activating outward rectifier potassium currents in reponse to high intracellular sodium and chloride levels. Its channel activity is inhibited by ATP, inhalation anesthetics, such as isoflourane, and upon stimulation of G-protein coupled receptors, such as mAChR M1 and GluR-1. There are four isoforms of KCNT2 that are produced as a result of alternative splicing events.

Subcellular location: Extracellular

Synonyms: KCa4.2, Potassium channel, subfamily T, member 2, Sequence like an intermediate conductance potassium channel subunit, SLICK, SLO2.1, Sodium and chloride activated ATP sensitive potassium channel, Sodium and chloride activated ATP sensitive potassium channel Slo2.1, KCNT2_HUMAN.