ZNRF3 antibody (PE-Cy7)

Catalog No. ABIN1434641

The Rabbit Polyclonal anti-ZNRF3 antibody has been validated for IF (p). It is suitable to detect ZNRF3 in samples from Human, Mouse, Rat, Chicken, Cow, Dog and Pig.

Quick Overview for ZNRF3 antibody (PE-Cy7) (ABIN1434641)

Target: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Reactivity: Human, Mouse, Rat, Chicken, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNRF3 antibody is conjugated to PE-Cy7

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ZNRF3 Antibody (PE-Cy7)

Cross-Reactivity: Rat (Rattus), Chicken, Dog (Canine), Pig (Porcine), Cow (Bovine)

Purification: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human ZNRF3

Isotype: IgG

Application Details

Comment:

Excitation / Emission wavelength: 496,565nm / 774nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % Gentamicin.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4 °C for 12 months

Expiry Date: 12 months

Target Details for ZNRF3

Target: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Alternative Name: ZNRF3

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF3 (Zinc/RING finger protein 3), also known as RNF203 (RING finger protein 203), is a 936 amino acid single pass transmembrane protein that contains one RING-type zinc finger. Related zinc/RING finger proteins, such as ZNRF1 and ZNRF2, are E3 ubiquitin-protein ligases that are thought to be involved in the establishment and maintenance of neuronal transmission and plasticity, therefore it is likely that ZNRF3 may function in a similar manner.

Gene ID: 84133

HGNC: 0

Pathways: WNT Signaling