CCR5 antibody

Catalog No. ABIN1449163

This Rat Monoclonal antibody specifically detects CCR5 in FACS. It exhibits reactivity toward Human.

Quick Overview for CCR5 antibody (ABIN1449163)

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This CCR5 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: T227

Product Details anti-CCR5 Antibody

Specificity: This antibody reacts with CD195 antigen.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Ammonium sulfate precipitation followed by gel filtration through Superdex 200 in PBS

Immunogen: Syngeneic human CD195 transfectants

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CCR5

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Alternative Name: CD195 / CCR5

Background: CD195/CCR5, is a seven transmembrane receptor that is a member of the ß-chemokine receptor family. CCR5 is expressed by T cells and macrophages, and is one of the two major co-receptors for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with resistance to HIV infection, and early infection with HIV-1 is dominated by CCR5-tropic viruses. The ligands of the CCR5 receptor include MCP-2, MIP-1a, MIP-1ß, and RANTES. CCR5 is phosphorylated at specific sites by protein kinase C and GPCR kinase, and data show that two distinct forms of CCR5 protein, 62 and 42 kDa, are present in lymphocytic cells. CCR5 expression was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.Synonyms: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor

Gene ID: 1234

NCBI Accession: NP_000570

UniProt: P51681

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size