ABI1 antibody

Catalog No. ABIN1449186

This anti-ABI1 antibody is a Mouse Monoclonal antibody detecting ABI1 in WB, IP and IHC (p). Suitable for Human, Mouse and Hamster.

Quick Overview for ABI1 antibody (ABIN1449186)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Reactivity: Human, Mouse, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1B9

Product Details anti-ABI1 Antibody

Specificity: This antibody reacts with Abi-1.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Hamster

Purification: Protein A agarose

Immunogen: Human recombinant Abi-1 expressed in E. coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Alternative Name: ABI1 / SSH3BP1

Background: Abl interactor (Abi) proteins are c-Abl-binding proteins that bind to both the Src homology 3 (SH3) domain and the C-terminal proline-rich regions of Abl kinase through dual SH3-PXXP interactions. Two highly related genes, abi-1 and abi-2, were cloned. In addition to the interaction with Abl kinase, Abi proteins also interact with other signaling molecules. Recently, it has been reported that Abi-1 dramatically promoted c-Abl-mediated tyrosine (Tyr296) phosphorylation of Mena [mammalian homologue of Drosophila Enabled (Ena)] by interacting with both proteins.Synonyms: Abelson interactor 1, Abi-1, Abl interactor 1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Nap1-binding protein, Spectrin SH3 domain-binding protein 1, Spectrin binding protein, e3B1

Molecular Weight: 65 kDa

Gene ID: 10006

NCBI Accession: NP_001012768

UniProt: Q8IZP0

Pathways: RTK Signaling, Response to Water Deprivation, ER-Nucleus Signaling