Mesothelin antibody

Catalog No. ABIN1449246

The Rat Monoclonal anti-Mesothelin antibody (Clone B35) (ABIN1449246) specifically detects Mesothelin in FACS. The antibody is reactive with Mouse samples.

Quick Overview for Mesothelin antibody (ABIN1449246)

Target: Mesothelin (MSLN)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Mesothelin antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: B35

Product Details anti-Mesothelin Antibody

Specificity: This antibody reacts with mouse mesothelin.

Purification: Protein G agarose

Immunogen: Murine hemangioblast-like cell line LO

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for Mesothelin

Target: Mesothelin (MSLN)

Alternative Name: Mesothelin

Background: Mesothelin (MSLN) is a GPI-linked cell surface glycoprotein expressed in the mesothelial lining of the body cavities and in mullerian duct epithelium related cancer cells (ovarian, pancreatic cancer, mesothelioma). Both human and mouse mesothelin bind to ovarian cancer antigen CA125/MUC16 with high affinity, mediating cell attachment in vitro , suggesting that mesothelin may facilitate ovarian cancer metastasis.Synonyms: CAK1 antigen, MPF, MSLN, Pre-pro-megakaryocyte-potentiating factor

Gene ID: 56047

NCBI Accession: NP_061345

UniProt: Q61468

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process