PRC1 antibody (Middle Region)

Catalog No. ABIN1449936

The Rabbit Polyclonal anti-PRC1 antibody (ABIN1449936) specifically detects PRC1 in WB, IF, IHC (p) and EIA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PRC1 antibody (Middle Region) (ABIN1449936)

Target: PRC1 (Protein Regulator of Cytokinesis 1 (PRC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-PRC1 Antibody

Binding Specificity: Middle Region

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near the center of Human PRC1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PRC1

Target: PRC1 (Protein Regulator of Cytokinesis 1 (PRC1))

Alternative Name: PRC1

Background: PRC1 (Protein Regulator of Cytokinesis 1) is a key regulator of cytokinesis and has been identified as a substrate for several cyclin-dependent kinases (CDKs). High levels of PRC1 expression occurs during S and G2/M and drops dramatically after mitosis exit and G1 entry. It is located in the nucleus during interphase and binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis.Synonyms: ASE1, Protein regulator of cytokinesis 1

Gene ID: 9055

NCBI Accession: NP_003972