WDR35 antibody (N-Term)

Catalog No. ABIN1449959

The Rabbit Polyclonal anti-WDR35 antibody has been validated for IHC (p) and EIA. It is suitable to detect WDR35 in samples from Human.

Quick Overview for WDR35 antibody (N-Term) (ABIN1449959)

Target: WDR35 (WD Repeat Domain 35 (WDR35))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR35 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-WDR35 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the amino terminus of Human WDR35

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for WDR35

Target: WDR35 (WD Repeat Domain 35 (WDR35))

Alternative Name: WDR35

Background: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.Synonyms: IFT121, Intraflagellar transport protein 121 homolog, KIAA1336, WD repeat-containing protein 35

Gene ID: 57539

NCBI Accession: NP_001006658

Pathways: Hedgehog Signaling