CARD10 antibody (N-Term)

Catalog No. ABIN1449965

The Rabbit Polyclonal anti-CARD10 antibody has been validated for IHC (p) and EIA. It is suitable to detect CARD10 in samples from Human.

Quick Overview for CARD10 antibody (N-Term) (ABIN1449965)

Target: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD10 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-CARD10 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the amino terminus of human CARMA3

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CARD10

Target: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Alternative Name: CARD10 / CARMA3

Background: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein binds to BCL10 and activates NF-kB Recent experiments have shown that CARMA3 is required for EGF-induced NF-kB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.Synonyms: BIMP1, CARD10, Caspase recruitment domain family member 10

Gene ID: 29775

NCBI Accession: NP_055365

Pathways: S100 Proteins