AFAP antibody (N-Term)

Catalog No. ABIN1450096

This Rabbit Polyclonal antibody specifically detects AFAP in WB and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for AFAP antibody (N-Term) (ABIN1450096)

Target: AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFAP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-AFAP Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: AFAP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of Human AFAP1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AFAP

Target: AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))

Alternative Name: AFAP1

Background: The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.Synonyms: 110 kDa actin filament-associated protein, AFAP-110, Actin filament-associated protein 1

Gene ID: 60312

NCBI Accession: NP_940997