SIGLEC15 antibody (N-Term)

Catalog No. ABIN1450134

The Rabbit Polyclonal anti-SIGLEC15 antibody (ABIN1450134) specifically detects SIGLEC15 in WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SIGLEC15 antibody (N-Term) (ABIN1450134)

Target: SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGLEC15 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SIGLEC15 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (expected):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the amino terminus of Human SIGLEC15

Isotype: IgG

Application Details

Application Notes: WB: 1 - 2 ug/mL, IHC: 2.5 ug/mL
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SIGLEC15

Target: SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))

Alternative Name: SIGLEC15 / CD33L3

Background: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.Synonyms: CD33 antigen-like 3, SIGLEC-15, Sialic acid-binding Ig-like lectin 15

Gene ID: 284266

NCBI Accession: NP_998767