TET2 antibody (N-Term)

Catalog No. ABIN1450172

The Rabbit Polyclonal anti-TET2 antibody is suitable to detect TET2 in samples from Human. It has been validated for WB and EIA.

Quick Overview for TET2 antibody (N-Term) (ABIN1450172)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TET2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-TET2 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid synthetic peptide near the amino terminus of Human TET2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Alternative Name: TET2

Background: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14 % of patients with JAK2V617F-positive myeloproliferative neoplasms, and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.Synonyms: KIAA1546, Methylcytosine dioxygenase TET2

Gene ID: 54790

NCBI Accession: NP_001120680

Pathways: Warburg Effect