Complement Factor I antibody (AA 441-490)

Catalog No. ABIN1451187

The Rabbit Polyclonal anti-Complement Factor I antibody (ABIN1451187) specifically detects Complement Factor I in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Complement Factor I antibody (AA 441-490) (ABIN1451187)

Target: Complement Factor I (CFI)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor I antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Complement Factor I Antibody

Binding Specificity: AA 441-490

Purpose: Factor I Antibody

Specificity: Factor I Polyclonal Antibody detects endogenous levels of Factor I protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human CFI. AA range:441-490

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Complement Factor I

Target: Complement Factor I (CFI)

Alternative Name: CFI

Background:

Synonyms: CFI, IF, Complement factor I, C3B/C4B inactivator

Background: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by Ref

Gene Name: CFI

Protein Name: Complement factor I

Molecular Weight: 65 kDa

Gene ID: 3426

OMIM: 217030

UniProt: P05156

Pathways: Complement System