MASP2 antibody (AA 227-276)

Catalog No. ABIN1451319

The Rabbit Polyclonal anti-MASP2 antibody (ABIN1451319) specifically detects MASP2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MASP2 antibody (AA 227-276) (ABIN1451319)

Target: MASP2 (Mannan-Binding Lectin serine Peptidase 2 (MASP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MASP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MASP2 Antibody

Binding Specificity: AA 227-276

Purpose: MASP-2 Antibody

Specificity: MASP-2 Polyclonal Antibody detects endogenous levels of MASP-2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human MASP2. AA range:227-276

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MASP2

Target: MASP2 (Mannan-Binding Lectin serine Peptidase 2 (MASP2))

Alternative Name: MASP2

Background:

Synonyms: MASP2, Mannan-binding lectin serine protease 2, MBL-associated serine protease 2, Mannose-binding protein-associated serine protease 2, MASP-2

Background: mannan binding lectin serine peptidase 2(MASP2) Homo sapiens This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],

Gene Name: MASP2

Protein Name: Mannan-binding lectin serine protease 2

Molecular Weight: 75 kDa

Gene ID: 10747

OMIM: 605102

UniProt: O00187

Pathways: Complement System