RAPGEF3 antibody (AA 712-761)

Catalog No. ABIN1451502

The Rabbit Polyclonal anti-RAPGEF3 antibody (ABIN1451502) specifically detects RAPGEF3 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RAPGEF3 antibody (AA 712-761) (ABIN1451502)

Target: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAPGEF3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RAPGEF3 Antibody

Binding Specificity: AA 712-761

Purpose: Epac Antibody

Specificity: Epac Polyclonal Antibody detects endogenous levels of Epac protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human RAPGEF3. AA range:712-761

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for RAPGEF3

Target: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Alternative Name: RAPGEF3

Background:

Synonyms: RAPGEF3, CGEF1, EPAC, EPAC1, Rap guanine nucleotide exchange factor 3, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, EPAC 1, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP,

Background: caution:It is uncertain whether Met-1 or Met-43 is the initiator.,domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.,

Gene Name: RAPGEF3

Protein Name: Rap guanine nucleotide exchange factor 3

Molecular Weight: 99 kDa

Gene ID: 10411

OMIM: 606057

UniProt: O95398

Pathways: cAMP Metabolic Process