Desmoglein 1 antibody (AA 161-210)

Catalog No. ABIN1452168

The Rabbit Polyclonal anti-Desmoglein 1 antibody (ABIN1452168) specifically detects Desmoglein 1 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for Desmoglein 1 antibody (AA 161-210) (ABIN1452168)

Target: Desmoglein 1 (DSG1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Desmoglein 1 Antibody

Binding Specificity: AA 161-210

Purpose: Dsg1 Antibody

Specificity: Dsg1 Polyclonal Antibody detects endogenous levels of Dsg1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human DSG1. AA range:161-210

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: DSG1

Background:

Synonyms: DSG1, CDHF4, Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen

Background: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015],

Gene Name: DSG1

Protein Name: Desmoglein-1

Molecular Weight: 113 kDa

Gene ID: 1828

OMIM: 125670

UniProt: Q02413

Pathways: Cell-Cell Junction Organization