VASH1 antibody (AA 261-310)

Catalog No. ABIN1452171

The Rabbit Polyclonal anti-VASH1 antibody (ABIN1452171) specifically detects VASH1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for VASH1 antibody (AA 261-310) (ABIN1452171)

Target: VASH1 (Vasohibin 1 (VASH1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VASH1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-VASH1 Antibody

Binding Specificity: AA 261-310

Purpose: Vasohibin Antibody

Specificity: Vasohibin Polyclonal Antibody detects endogenous levels of Vasohibin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human VASH1. AA range:261-310

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for VASH1

Target: VASH1 (Vasohibin 1 (VASH1))

Alternative Name: VASH1

Background:

Synonyms: VASH1, KIAA1036, VASH, Vasohibin-1

Background: caution:Although probably secreted, it lacks a canonical signal sequence.,function:Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.,induction:By VEGF.,PTM:2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form.,similarity:Belongs to the vasohibin family.,tissue specificity:Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.,

Gene Name: VASH1

Protein Name: Vasohibin-1

Molecular Weight: 40 kDa

Gene ID: 22846

OMIM: 609011

UniProt: Q7L8A9