Cathepsin B antibody (AA 168-217)

Catalog No. ABIN1453029

The Rabbit Polyclonal anti-Cathepsin B antibody (ABIN1453029) specifically detects Cathepsin B in WB, IHC, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Cathepsin B antibody (AA 168-217) (ABIN1453029)

Target: Cathepsin B (CTSB)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-Cathepsin B Antibody

Binding Specificity: AA 168-217

Purpose: Cathepsin B Antibody

Specificity: Cathepsin B Polyclonal Antibody detects endogenous levels of Cathepsin B protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human Cathepsin B. AA range:168-217

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Cathepsin B

Target: Cathepsin B (CTSB)

Alternative Name: Cathepsin B

Background:

Synonyms: CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1

Background: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors.

Gene Name: CTSB

Protein Name: Cathepsin B

Molecular Weight: 37 kDa

Gene ID: 1508

OMIM: 116810

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades