IDH2 antibody

Catalog No. ABIN1453428

The Rabbit Polyclonal anti-IDH2 antibody (ABIN1453428) specifically detects IDH2 in WB, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for IDH2 antibody (ABIN1453428)

Target: IDH2 (Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IDH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-IDH2 Antibody

Purpose: IDHP Antibody

Specificity: This antibody detects endogenous levels of human IDHP

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human IDHP

Isotype: IgG

Application Details

Application Notes: IHC 1:50-200, WB 1:500-2000. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for IDH2

Target: IDH2 (Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))

Alternative Name: IDH2

Background:

Synonyms: Isocitrate dehydrogenase [NADP], mitochondrial (IDH, EC 1.1.1.42, ICD-M, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase)

Background: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer.The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by Ref

Gene Name: IDH2

Protein Name: IDHP

Molecular Weight: 50 kDa

Gene ID: 3418

OMIM: 147650

UniProt: P48735

Pathways: Warburg Effect