SFTPB antibody (AA 243-292)

Catalog No. ABIN1453953

The Rabbit Polyclonal anti-SFTPB antibody (ABIN1453953) specifically detects SFTPB in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SFTPB antibody (AA 243-292) (ABIN1453953)

Target: SFTPB (Surfactant Protein B (SFTPB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SFTPB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SFTPB Antibody

Binding Specificity: AA 243-292

Purpose: SP-B Antibody

Specificity: SP-B Polyclonal Antibody detects endogenous levels of SP-B protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human SP-B. AA range:243-292

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SFTPB

Target: SFTPB (Surfactant Protein B (SFTPB))

Alternative Name: SP-B

Background:

Synonyms: SFTPB, SFTP3, Pulmonary surfactant-associated protein B, SP-B, 18 kDa pulmonary-surfactant protein, 6 kDa protein, Pulmonary surfactant-associated proteolipid SPL(Phe)

Background: This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90 % lipids and 10 % proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced trans

Gene Name: SFTPB

Protein Name: Pulmonary surfactant-associated protein B

Molecular Weight: 42 kDa

Gene ID: 6439

OMIM: 178640

UniProt: P07988