MAFK antibody

Catalog No. ABIN1504391

The Mouse Monoclonal anti-MAFK antibody has been validated for WB and EIA. It is suitable to detect MAFK in samples from Human.

Quick Overview for MAFK antibody (ABIN1504391)

Target: MAFK (Transcription Factor MafK (MAFK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAFK antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT2F7

Product Details anti-MAFK Antibody

Purification: Protein-A affinity chromatography

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) containing 10 % Glycerol, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for MAFK

Target: MAFK (Transcription Factor MafK (MAFK))

Alternative Name: MAFK

Background: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG or MafK) and p45. Since Maf homodimers lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. The MafK of Maf proteins is primarily expressed during development in mesenchymal and hematopoietic cells and neurons.Synonyms: Transcription factor MafK, v-maf musculoaponeurotic fibrosarcoma oncogene homolog K