TNFAIP3 antibody (AA 1-190)

Catalog No. ABIN3022985

This anti-TNFAIP3 antibody is a Rabbit Polyclonal antibody detecting TNFAIP3 in WB and IHC. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for TNFAIP3 antibody (AA 1-190) (ABIN3022985)

Target: TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFAIP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TNFAIP3 Antibody

Binding Specificity: AA 1-190

Sequence: MAEQVLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF REIIHKALID RNIQATLESQ KKLNWCREVR KLVALKTNGD GNCLMHATSQ YMWGVQDTDL VLRKALFSTL KETDTRNFKF RWQLESLKSQ EFVETGLCYD TRNWNDEWDN LIKMASTDTP MARSGLQYNS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TNFAIP3 (NP_006281.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-TNFAIP3 antibody (ABIN3022985)

He, Ma, Tian, Wei, Zhu, Li, Zhang, Wang, Zhang, Zhong: "ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction." in: PLoS pathogens, Vol. 13, Issue 6, pp. e1006347, (2017) (PubMed).

Target Details for TNFAIP3

Target: TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))

Alternative Name: TNFAIP3

Background: This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.,A20,AISBL,OTUD7C,TNFA1P2,TNFAIP3,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Growth factor,TNF,Ubiquitin,Immunology & Inflammation,Cytokines,TNF,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TNFAIP3

Molecular Weight: 89 kDa

Gene ID: 7128

UniProt: P21580

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Production of Molecular Mediator of Immune Response