TNFAIP3 antibody (AA 97-183)
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- Target See all TNFAIP3 Antibodies
- TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))
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Binding Specificity
- AA 97-183
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TNFAIP3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Tumor necrosis factor alpha-induced protein 3 protein (97-183AA)
- Isotype
- IgG
- Top Product
- Discover our top product TNFAIP3 Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))
- Alternative Name
- TNFAIP3 (TNFAIP3 Products)
- Synonyms
- tnfaip3 antibody, MGC82339 antibody, TNFAIP3 antibody, A20 antibody, OTUD7C antibody, TNFA1P2 antibody, Tnfip3 antibody, TNF alpha induced protein 3 antibody, TNF alpha induced protein 3 S homeolog antibody, tumor necrosis factor, alpha-induced protein 3 antibody, TNFAIP3 antibody, tnfaip3.S antibody, Tnfaip3 antibody
- Background
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Background: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways, affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates \\\'Lys-63\\\'-polyubiquitin chains on RIPK1 and catalyzes the formation of \\\'Lys-48\\\'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on \\\'Lys-63\\\'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates \\\'Lys-63\\\'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG, the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin, polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate \\\'Lys-11\\\'-, \\\'Lys-48\\\'- and \\\'Lys-63\\\' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.
Aliases: A20 antibody, AISBL antibody, MGC104522 antibody, MGC138687 antibody, MGC138688 antibody, OTU domain containing protein 7C antibody, OTU domain-containing protein 7C antibody, OTUD7C antibody, Putative DNA binding protein A20 antibody, Putative DNA-binding protein A20 antibody, TNAP3_HUMAN antibody, TNF alpha-induced protein 3 antibody, TNFA1P2 antibody, TNFAIP 3 antibody, TNFAIP3 (A20) antibody, TNFAIP3 antibody, Tumor necrosis factor alpha induced protein 3 antibody, Tumor necrosis factor alpha-induced protein 3 antibody, Tumor necrosis factor induced protein 3 antibody, Tumor necrosis factor inducible protein A20 antibody, tumor necrosis factor, alpha-induced protein 3 antibody, Zinc finger protein A20 antibody
- UniProt
- P21580
- Pathways
- TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Production of Molecular Mediator of Immune Response
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