WASP antibody (AA 60-250)

Catalog No. ABIN3021208

The Rabbit Polyclonal anti-WASP antibody has been validated for WB. It is suitable to detect WASP in samples from Human.

Quick Overview for WASP antibody (AA 60-250) (ABIN3021208)

Target: WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WASP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WASP Antibody

Binding Specificity: AA 60-250

Sequence: GAEHWTKEHC GAVCFVKDNP QKSYFIRLYG LQAGRLLWEQ ELYSQLVYST PTPFFHTFAG DDCQAGLNFA DEDEAQAFRA LVQEKIQKRN QRQSGDRRQL PPPPTPANEE RRGGLPPLPL HPGGDQGGPP VGPLSLGLAT VDIQNPDITS SRYRGLPAPG PSPADKKRSG KKKISKADIG APSGFKHVSH V

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human WASPP (NP_000368.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for WASP

Target: WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))

Alternative Name: WAS

Background: The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.,WAS,IMD2,SCNX,THC,THC1,WASP,WASPA,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Actins,Immunology & Inflammation,T Cell Receptor Signaling Pathway,WAS

Molecular Weight: 52 kDa

Gene ID: 7454

UniProt: P42768