STXBP1 antibody (pSer313)

Catalog No. ABIN1531345

The Rabbit Polyclonal anti-STXBP1 antibody is suitable to detect STXBP1 in samples from Human, Mouse, Rat and Monkey. It has been validated for WB and ELISA.

Quick Overview for STXBP1 antibody (pSer313) (ABIN1531345)

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STXBP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-STXBP1 Antibody

Binding Specificity: AA 279-328, pSer313

Purpose: Unc18-1 (phospho Ser313) Antibody

Specificity: Phospho-Unc18-1 (S313) Polyclonal Antibody detects endogenous levels of Unc18-1 protein only when phosphorylated at S313.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MUNC-18a around the phosphorylation site of Ser313. AA range:279-328

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for STXBP1

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Alternative Name: MUNC-18a

Background:

Synonyms: STXBP1, UNC18A, Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67

Background: This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010],

Gene Name: STXBP1

Protein Name: Syntaxin-binding protein 1

Molecular Weight: 67 kDa

Gene ID: 6812

OMIM: 602926

UniProt: P61764

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport