Survivin antibody (pThr117)

Catalog No. ABIN1531396

The Rabbit Polyclonal anti-Survivin antibody is suitable to detect Survivin in samples from Human, Mouse and Rat. It has been validated for ELISA, IHC and IF.

Quick Overview for Survivin antibody (pThr117) (ABIN1531396)

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Survivin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Survivin Antibody

Binding Specificity: AA 86-135, pThr117

Specificity:

Survivin (Phospho-Thr117) Antibody detects endogenous levels of Survivin only when phosphorylated at Thr117.

PhosphorylationH:T117 M:T117 R:T117

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Survivin around the phosphorylation site of Thr117.

Isotype: IgG

Application Details

Application Notes: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000

Comment:

Unigene-Number: Hs.514527 (NCBI Gene Symbol: BIRC5)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable at -20°C for at least 1 year.

Expiry Date: 12 months

Target Details for Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Alternative Name: Survivin

Background:

Synonyms: API4, apoptosis inhibitor 4, apoptosis inhibitor survivin, baculoviral IAP repeat-containing protein 5, BIRC5, IAP4, TIAP

NCBI Gene Symbol: BIRC5

Molecular Weight: 16 kDa

Gene ID: 332

OMIM: 603352

UniProt: O15392

Pathways: Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding