Fc gamma RII (CD32) (AA 258-307), (pTyr292) antibody

Catalog No. ABIN1531425

The Rabbit Polyclonal anti-Fc gamma RII antibody (ABIN1531425) specifically detects Fc gamma RII in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Fc gamma RII (CD32) (AA 258-307), (pTyr292) antibody (ABIN1531425)

Target: Fc gamma RII (CD32)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Product Details

Binding Specificity: AA 258-307, pTyr292

Purpose: CD32 (phospho Tyr292) Antibody

Specificity: Phospho-CD32 (Y292) Polyclonal Antibody detects endogenous levels of CD32 protein only when phosphorylated at Y292.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human CD32 around the phosphorylation site of Tyr292. AA range:258-307

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details

Target: Fc gamma RII (CD32)

Alternative Name: CD32

Background:

Synonyms: FCGR2B, CD32, FCG2, IGFR2, Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD antigen CD32

Background: The Fc fragment of IgG receptor IIb encoded by FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.

Gene Name: FCGR2B

Protein Name: Low affinity immunoglobulin gamma Fc region receptor II-b

Molecular Weight: 34 kDa

Gene ID: 2213

OMIM: 604590

UniProt: P31994