HRH1 antibody (pSer398)

Catalog No. ABIN1531653

The Rabbit Polyclonal anti-HRH1 antibody (ABIN1531653) specifically detects HRH1 in ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for HRH1 antibody (pSer398) (ABIN1531653)

Target: HRH1 (Histamine Receptor H1 (HRH1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRH1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-HRH1 Antibody

Binding Specificity: AA 364-413, pSer398

Purpose: Histamine H1 Receptor (phospho Ser398) Antibody

Specificity: Phospho-Histamine H1 Receptor (S398) Polyclonal Antibody detects endogenous levels of Histamine H1 Receptor protein only when phosphorylated at S398.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Histamine H1 Receptor around the phosphorylation site of Ser398. AA range:364-413

Isotype: IgG

Application Details

Application Notes: IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for HRH1

Target: HRH1 (Histamine Receptor H1 (HRH1))

Alternative Name: Histamine H1 Receptor

Background:

Synonyms: HRH1, Histamine H1 receptor, H1R, HH1R

Background: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4.The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by Ref

Gene Name: HRH1

Protein Name: Histamine H1 receptor

Molecular Weight: 55 kDa

Gene ID: 3269

OMIM: 600167

UniProt: P35367

Pathways: Regulation of Carbohydrate Metabolic Process