SNAIL antibody (pSer246)

Catalog No. ABIN1531754

The Rabbit Polyclonal anti-SNAIL antibody is suitable to detect SNAIL in samples from Human, Mouse and Monkey. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for SNAIL antibody (pSer246) (ABIN1531754)

Target: SNAIL (SNAI1)

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SNAIL Antibody

Binding Specificity: AA 215-264, pSer246

Purpose: SNAI 1 (phospho Ser246) Antibody

Specificity: Phospho-SNAI 1 (S246) Polyclonal Antibody detects endogenous levels of SNAI 1 protein only when phosphorylated at S246.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SNAI1 around the phosphorylation site of Ser246. AA range:215-264

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1

Background:

Synonyms: SNAI1, SNAH, Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna

Background: snail family transcriptional repressor 1(SNAI1) Homo sapiens The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008],

Gene Name: SNAI1

Protein Name: Zinc finger protein SNAI1(snail)

Molecular Weight: 29 kDa

Gene ID: 6615

OMIM: 604238

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling