Claudin 7 antibody (pTyr210)

Catalog No. ABIN1532134

The Rabbit Polyclonal anti-Claudin 7 antibody is suitable to detect Claudin 7 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Claudin 7 antibody (pTyr210) (ABIN1532134)

Target: Claudin 7 (CLDN7)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Claudin 7 Antibody

Binding Specificity: AA 162-211, pTyr210

Purpose: Claudin-7 (phospho Tyr210) Antibody

Specificity: Phospho-Claudin-7 (Y210) Polyclonal Antibody detects endogenous levels of Claudin-7 protein only when phosphorylated at Y210.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Claudin 7 around the phosphorylation site of Tyr210. AA range:162-211

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Claudin 7

Target: Claudin 7 (CLDN7)

Alternative Name: Claudin 7

Background:

Synonyms: CLDN7, CEPTRL2, CPETRL2, Claudin-7, CLDN-7

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010],

Gene Name: CLDN7

Protein Name: Claudin-7

Molecular Weight: 22 kDa

Gene ID: 1366

OMIM: 609131

UniProt: O95471

Pathways: Hepatitis C