ITPR1 antibody (pSer1764)

Catalog No. ABIN1532147

Product Details anti-ITPR1 Antibody

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Binding Specificity: AA 1730-1779, pSer1764

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPR1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Specificity:

IP3R1 (Phospho-Ser1764) Antibody detects endogenous levels of IP3R1 only when phosphorylated at Ser1764.

PhosphorylationH:S1764 M:S1755 R:S1756

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human IP3R1 around the phosphorylation site of Ser1764.

Isotype: IgG

Application Details

Application Notes: IHC: 1:50~1:100 ELISA: 1:1000

Comment:

Unigene-Number: Hs.567295, Hs.712541 (NCBI Gene Symbol: ITPR1)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable at -20°C for at least 1 year.

Expiry Date: 12 months

Target Details for ITPR1

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Alternative Name: IP3R1 (ITPR1 Products)

Background:

Synonyms: Inositol 1,4,5-trisphosphate receptor type 1, InsP3R1, IP3 receptor isoform 1, IP3R, ITPR1, Type 1 inositol 1,4,5- trisphosphate receptor, Type 1 InsP3 receptor

NCBI Gene Symbol: ITPR1

Molecular Weight: 313 kDa

Gene ID: 3708

OMIM: 147265

UniProt: Q14643

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma