PAK5/6 (AA 566-615), (pSer560), (pSer602) antibody

Catalog No. ABIN1532164

The Rabbit Polyclonal anti-PAK5/6 antibody (ABIN1532164) specifically detects PAK5/6 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for PAK5/6 (AA 566-615), (pSer560), (pSer602) antibody (ABIN1532164)

Target: PAK5/6

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Product Details

Binding Specificity: AA 566-615, pSer560, pSer602

Purpose: PAK5/6 (phospho Ser602/S560) Antibody

Specificity: Phospho-PAK5/6 (S602/S560) Polyclonal Antibody detects endogenous levels of PAK5/6 protein only when phosphorylated at S602/S560.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PAK5/6 around the phosphorylation site of Ser602/Ser560. AA range:566-615

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details

Target: PAK5/6

Background:

Synonyms: PAK7, KIAA1264, PAK5, Serine/threonine-protein kinase PAK 7, p21-activated kinase 5, PAK-5, p21-activated kinase 7, PAK-7, PAK6, PAK5, Serine/threonine-protein kinase PAK 6, PAK-5, p21-activated kinase 6, PAK-6

Background: The protein encoded byThis gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],

Gene Name: PAK6/PAK7

Protein Name: Serine/threonine-protein kinase PAK 6/7

Molecular Weight: 74 kDa

Gene ID: 57144, 56924

OMIM: 608038

UniProt: Q9P286