Ataxin 1 antibody (AA 742-791)

Catalog No. ABIN1532502

This Rabbit Polyclonal antibody specifically detects Ataxin 1 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Ataxin 1 antibody (AA 742-791) (ABIN1532502)

Target: Ataxin 1 (ATXN1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-Ataxin 1 Antibody

Binding Specificity: AA 742-791

Purpose: Ataxin-1 Antibody

Specificity: Ataxin-1 Polyclonal Antibody detects endogenous levels of Ataxin-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Ataxin 1. AA range:742-791

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Ataxin 1

Target: Ataxin 1 (ATXN1)

Alternative Name: Ataxin 1

Background:

Synonyms: ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein

Background: ataxin 1(ATXN1) Homo sapiens The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted

Gene Name: ATXN1

Protein Name: Ataxin-1

Molecular Weight: 87 kDa

Gene ID: 6310

OMIM: 164400

UniProt: P54253

Pathways: Synaptic Membrane