HTRA2 antibody (AA 181-230)

Catalog No. ABIN1533174

The Rabbit Polyclonal anti-HTRA2 antibody is suitable to detect HTRA2 in samples from Human, Mouse and Rat. It has been validated for ELISA, IF (p) and IHC (p).

Quick Overview for HTRA2 antibody (AA 181-230) (ABIN1533174)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA2 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HTRA2 Antibody

Binding Specificity: AA 181-230

Purpose: HtrA2 Antibody

Specificity: HtrA2 Polyclonal Antibody detects endogenous levels of HtrA2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human HtrA2. AA range:181-230

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HtrA2

Background:

Synonyms: HTRA2, OMI, PRSS25, Serine protease HTRA2, mitochondrial, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI

Background: programmed cell death 1(PDCD1) Homo sapiens This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],

Gene Name: HTRA2

Protein Name: Serine protease HTRA2 mitochondrial

Molecular Weight: 48 kDa

OMIM: 168600

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity