SENP6 antibody (AA 1042-1091)

Catalog No. ABIN1533440

The Rabbit Polyclonal anti-SENP6 antibody (ABIN1533440) specifically detects SENP6 in ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SENP6 antibody (AA 1042-1091) (ABIN1533440)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP6 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SENP6 Antibody

Binding Specificity: AA 1042-1091

Purpose: SENP6 Antibody

Specificity: SENP6 Polyclonal Antibody detects endogenous levels of SENP6 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SENP6. AA range:1042-1091

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Alternative Name: SENP6

Background:

Synonyms: SENP6, KIAA0797, SSP1, SUSP1, FKSG6, Sentrin-specific protease 6, SUMO-1-specific protease 1, Sentrin/SUMO-specific protease SENP6

Background: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for

Gene Name: SENP6

Protein Name: Sentrin-specific protease 6

Molecular Weight: 126 kDa

Gene ID: 26054

OMIM: 605003

UniProt: Q9GZR1