TRADD antibody (AA 251-300)

Catalog No. ABIN1533447

This Rabbit Polyclonal antibody specifically detects TRADD in WB, IHC, ELISA and IF. It exhibits reactivity toward Human, Mouse and Monkey.

Quick Overview for TRADD antibody (AA 251-300) (ABIN1533447)

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRADD antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-TRADD Antibody

Binding Specificity: AA 251-300

Purpose: TRADD Antibody

Specificity: TRADD Polyclonal Antibody detects endogenous levels of TRADD protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TRADD. AA range:251-300

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TRADD

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Alternative Name: TRADD

Background:

Synonyms: TRADD, Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain

Background: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008],

Gene Name: TRADD

Protein Name: Tumor necrosis factor receptor type 1-associated DEATH domain protein

Molecular Weight: 34 kDa

Gene ID: 8717

OMIM: 603500

UniProt: Q15628

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C