HMGB2 antibody (AA 131-180)

Catalog No. ABIN1533677

The Rabbit Polyclonal anti-HMGB2 antibody (ABIN1533677) specifically detects HMGB2 in WB, IHC, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for HMGB2 antibody (AA 131-180) (ABIN1533677)

Target: HMGB2 (High Mobility Group Box 2 (HMGB2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-HMGB2 Antibody

Binding Specificity: AA 131-180

Purpose: HMG-2 Antibody

Specificity: HMG-2 Polyclonal Antibody detects endogenous levels of HMG-2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human HMGB2. AA range:131-180

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for HMGB2

Target: HMGB2 (High Mobility Group Box 2 (HMGB2))

Alternative Name: HMGB2

Background:

Synonyms: HMGB2, HMG2, High mobility group protein B2, High mobility group protein 2, HMG-2

Background: This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008],

Gene Name: HMGB2

Protein Name: High mobility group protein B2

Molecular Weight: 24 kDa

Gene ID: 3148

OMIM: 163906

UniProt: P26583

Pathways: Cellular Response to Molecule of Bacterial Origin