PFKFB1/4 antibody (AA 331-380)

Catalog No. ABIN1533937

The Rabbit Polyclonal anti-PFKFB1/4 antibody is suitable to detect PFKFB1/4 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for PFKFB1/4 antibody (AA 331-380) (ABIN1533937)

Target: PFKFB1/4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1/4 (PFKFB1/4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKFB1/4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PFKFB1/4 Antibody

Binding Specificity: AA 331-380

Purpose: PFK-2 liv/tes Antibody

Specificity: PFK-2 liv/tes Polyclonal Antibody detects endogenous levels of PFK-2 liv/tes protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PFKFB1/4. AA range:331-380

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PFKFB1/4

Target: PFKFB1/4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1/4 (PFKFB1/4))

Alternative Name: PFKFB1/4

Background:

Synonyms: PFKFB1, F6PK, PFRX, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1, 6PF-2-K/Fru-2,6-P2ase 1, PFK/FBPase 1, 6PF-2-K/Fru-2,6-P2ase liver isozyme, PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6PF-2-K/Fru-2,6-P2ase 4,

Background: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012],

Gene Name: PFKFB1/PFKFB4

Protein Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1/4

Molecular Weight: 54 kDa

Gene ID: 5207, 5210

OMIM: 311790

UniProt: P16118