TNS3 antibody (AA 541-590)

Catalog No. ABIN1533957

This Rabbit Polyclonal antibody specifically detects TNS3 in IHC, ELISA and IF. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for TNS3 antibody (AA 541-590) (ABIN1533957)

Target: TNS3 (Tensin 3 (TNS3))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNS3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-TNS3 Antibody

Binding Specificity: AA 541-590

Purpose: Tensin3 Antibody

Specificity: Tensin3 Polyclonal Antibody detects endogenous levels of Tensin3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TENS3. AA range:541-590

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TNS3

Target: TNS3 (Tensin 3 (TNS3))

Background:

Synonyms: TNS3, TEM6, TENS1, TPP, Tensin-3, Tensin-like SH2 domain-containing protein 1, Tumor endothelial marker 6

Background: function:May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.,induction:EGF induces down-regulation.,PTM:Epidermal growth factor(EGF) induces tyrosine phosphorylation in a time- and dose-dependent manner.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:EGF promotes the interaction with EGFR. Interacts with PTK2 and BCAR1. Tyrosine phosphorylation is critical for these interactions.,tissue specificity:Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.,

Gene Name: TNS3

Protein Name: Tensin-3

Molecular Weight: 155 kDa

Gene ID: 64759

OMIM: 606825

UniProt: Q68CZ2