PHKB antibody (AA 661-710)

Catalog No. ABIN1534055

The Rabbit Polyclonal anti-PHKB antibody (ABIN1534055) specifically detects PHKB in WB and IHC. The antibody is reactive with Human and Mouse samples.

Quick Overview for PHKB antibody (AA 661-710) (ABIN1534055)

Target: PHKB (Phosphorylase Kinase, beta (PHKB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHKB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PHKB Antibody

Binding Specificity: AA 661-710

Purpose: PHKB Antibody

Specificity: PHKB Polyclonal Antibody detects endogenous levels of PHKB protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human KPBB. AA range:661-710

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PHKB

Target: PHKB (Phosphorylase Kinase, beta (PHKB))

Background:

Synonyms: PHKB, Phosphorylase b kinase regulatory subunit beta, Phosphorylase kinase subunit beta

Background: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency

Gene Name: PHKB

Protein Name: Phosphorylase b kinase regulatory subunit beta

Molecular Weight: 124 kDa

Gene ID: 5257

OMIM: 172490

UniProt: Q93100

Pathways: Cellular Glucan Metabolic Process