MKL1 antibody (AA 10-59)

Catalog No. ABIN1534057

This Rabbit Polyclonal antibody specifically detects MKL1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for MKL1 antibody (AA 10-59) (ABIN1534057)

Target: MKL1 (Megakaryoblastic Leukemia (Translocation) 1 (MKL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MKL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MKL1 Antibody

Binding Specificity: AA 10-59

Purpose: MRTF-A Antibody

Specificity: MRTF-A Polyclonal Antibody detects endogenous levels of MRTF-A protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MKL1. AA range:10-59

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for MKL1

Target: MKL1 (Megakaryoblastic Leukemia (Translocation) 1 (MKL1))

Alternative Name: MKL1

Background:

Synonyms: MKL1, KIAA1438, MAL, MKL/myocardin-like protein 1, Megakaryoblastic leukemia 1 protein, Megakaryocytic acute leukemia protein, Myocardin-related transcription factor A, MRTF-A

Background: The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

Gene Name: MKL1

Protein Name: MKL/myocardin-like protein 1

Molecular Weight: 98 kDa

Gene ID: 57591

OMIM: 606078

UniProt: Q969V6