LAMA3 antibody (AA 2571-2620)

Catalog No. ABIN1534453

The Rabbit Polyclonal anti-LAMA3 antibody is suitable to detect LAMA3 in samples from Human, Mouse and Rat. It has been validated for IHC, ELISA, IF and WB.

Quick Overview for LAMA3 antibody (AA 2571-2620) (ABIN1534453)

Target: LAMA3 (Laminin, alpha 3 (LAMA3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMA3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Western Blotting (WB)

Product Details anti-LAMA3 Antibody

Binding Specificity: AA 2571-2620

Purpose: Laminin α-3 Antibody

Specificity: Laminin α-3 Polyclonal Antibody detects endogenous levels of Laminin α-3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human LAMA3. AA range:2571-2620

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for LAMA3

Target: LAMA3 (Laminin, alpha 3 (LAMA3))

Alternative Name: LAMA3

Background:

Synonyms: LAMA3, LAMNA, Laminin subunit alpha-3, Epiligrin 170 kDa subunit, E170, Epiligrin subunit alpha, Kalinin subunit alpha, Laminin-5 subunit alpha, Laminin-6 subunit alpha, Laminin-7 subunit alpha, Nicein subunit alpha

Background: The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction.This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014],

Gene Name: LAMA3

Protein Name: Laminin subunit alpha-3

Molecular Weight: 189 kDa

Gene ID: 3909

OMIM: 226700

UniProt: Q16787