DPYSL4 antibody (AA 91-140)

Catalog No. ABIN1534832

The Rabbit Polyclonal anti-DPYSL4 antibody (ABIN1534832) specifically detects DPYSL4 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for DPYSL4 antibody (AA 91-140) (ABIN1534832)

Target: DPYSL4 (Dihydropyrimidinase-Like 4 (DPYSL4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYSL4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DPYSL4 Antibody

Binding Specificity: AA 91-140

Purpose: CRMP-3 Antibody

Specificity: CRMP-3 Polyclonal Antibody detects endogenous levels of CRMP-3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human DPYSL4. AA range:91-140

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for DPYSL4

Target: DPYSL4 (Dihydropyrimidinase-Like 4 (DPYSL4))

Alternative Name: DPYSL4

Background:

Synonyms: DPYSL4, CRMP3, ULIP4, Dihydropyrimidinase-related protein 4, DRP-4, Collapsin response mediator protein 3, CRMP-3, UNC33-like phosphoprotein 4, ULIP-4

Background: disease:Antibodies against post-translationally modified DPYSL4, also called anti-CV2 autoantibodies, are present in sera from patients with paraneoplastic neurological diseases (PND). PND are disorders of the nervous system associated with various systemic cancers which are not a direct result of the tumor mass or metastasis, but attributed to remote effects of the cancer.,function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.,

Gene Name: DPYSL4

Protein Name: Dihydropyrimidinase-related protein 4

Molecular Weight: 61 kDa

Gene ID: 10570

OMIM: 608407

UniProt: O14531