DMGDH antibody (AA 817-866)

Catalog No. ABIN1534834

The Rabbit Polyclonal anti-DMGDH antibody is suitable to detect DMGDH in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for DMGDH antibody (AA 817-866) (ABIN1534834)

Target: DMGDH (Dimethylglycine Dehydrogenase (DMGDH))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMGDH antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-DMGDH Antibody

Binding Specificity: AA 817-866

Purpose: DMGDH Antibody

Specificity: DMGDH Polyclonal Antibody detects endogenous levels of DMGDH protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human DMGDH. AA range:817-866

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for DMGDH

Target: DMGDH (Dimethylglycine Dehydrogenase (DMGDH))

Alternative Name: DMGDH

Background:

Synonyms: DMGDH, Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH

Background: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Gene Name: DMGDH

Protein Name: Dimethylglycine dehydrogenase mitochondrial

Molecular Weight: 96 kDa

Gene ID: 29958

OMIM: 605849

UniProt: Q9UI17