C1S antibody (Cleaved-Arg437)

Catalog No. ABIN1536125

The Rabbit Polyclonal anti-C1S antibody (ABIN1536125) specifically detects C1S in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for C1S antibody (Cleaved-Arg437) (ABIN1536125)

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1S antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C1S Antibody

Binding Specificity: AA 388-437, Cleaved-Arg437

Purpose: Cleaved-C1s HC (R437) Antibody

Specificity: Cleaved-C1s HC (R437) Polyclonal Antibody detects endogenous levels of fragment of activated C1s HC protein resulting from cleavage adjacent to R437.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human C1S. AA range:388-437

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for C1S

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Alternative Name: C1S

Background:

Synonyms: C1S, Complement C1s subcomponent, C1 esterase, Complement component 1 subcomponent s

Background: This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009],

Gene Name: C1S

Protein Name: Complement C1s subcomponent

Molecular Weight: 47 and 76 kDa

Gene ID: 716

OMIM: 120580

UniProt: P09871

Pathways: Complement System