PABPN1 antibody (C-Term)

Catalog No. ABIN1536983

The Rabbit Polyclonal anti-PABPN1 antibody has been validated for WB. It is suitable to detect PABPN1 in samples from Human.

Quick Overview for PABPN1 antibody (C-Term) (ABIN1536983)

Target: PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PABPN1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB36573

Product Details anti-PABPN1 Antibody

Binding Specificity: AA 270-298, C-Term

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PABPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-298 amino acids from the C-terminal region of human PABPN1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: PABPN1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for PABPN1

Target: PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))

Alternative Name: PABPN1

Background: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3' ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.

Molecular Weight: 32749

Gene ID: 8106

NCBI Accession: NP_004634

UniProt: Q86U42