Poly A Binding Protein Nuclear 1 (PABPN1) antibody

Details for Product No. ABIN6944405
Antigen
  • OPMD
  • PAB2
  • PABII
  • PABP-2
  • PABP2
  • Pabp3
  • mPABII
  • ARABIDOPSIS POLY(A) BINDING 2
  • ATPAB2
  • F28A23.130
  • F28A23_130
  • POLY(A) BINDING PROTEIN 2
  • POLY(A)-BINDING PROTEIN 2
  • poly(A) binding protein 2
  • poly(A) binding protein nuclear 1
  • poly(A) binding protein, nuclear 1
  • poly(A) binding protein 2
  • PABPN1
  • Pabpn1
  • PAB2
Reactivity
Human, Mouse (Murine)
50
25
4
3
3
3
3
3
1
Host
Rabbit
50
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
2
2
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
35
15
5
4
2
2
2
1
1
1
Options
Immunogen N terminus human PABPN1
Clone 1C1
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name PABPN1 (PABPN1 Antibody Abstract)
Background

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484).


Synonyms: Polyadenylate-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, Polyadenylate-binding nuclear protein 1, PABP-2, Poly(A)-binding protein 2, PABII, PABPN1
Gene ID 8106
UniProt Q86U42
Application Notes WB(1:300-1000), FCM(1:20-100), IHC-P(1:200-400), IF(ICC)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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