LKB1 antibody (C-Term)

Catalog No. ABIN1537274

There is 1 publication for this product available. The Rabbit Polyclonal anti-LKB1 antibody is suitable to detect LKB1 in samples from Human. It has been validated for IHC (p).

Quick Overview for LKB1 antibody (C-Term) (ABIN1537274)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LKB1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3549-3550

Product Details anti-LKB1 Antibody

Binding Specificity: AA 387-417, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This STK11 (LKB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-417 amino acids from the C-terminal region of human STK11 (LKB1).

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-LKB1 antibody (ABIN1537274)

Dahmani, Just, Delay, Canal, Finzi, Prip-Buus, Lambert, Sujobert, Buchet-Poyau, Miller, Cavard, Marmier, Terris, Billaud, Perret: "A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties." in: Oncogene, Vol. 34, Issue 18, pp. 2337-46, (2015) (PubMed).

Target Details for LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Alternative Name: STK11 (LKB1)

Background: STK11, is a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in STK11 have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms.

Molecular Weight: 48636

Gene ID: 6794

NCBI Accession: NP_000446

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect