BGLF4 (AA 386-417), (C-Term) antibody

Catalog No. ABIN1537299

Cited in 3+ publications. The Rabbit Polyclonal anti-BGLF4 antibody (Clone RB3734) (ABIN1537299) specifically detects BGLF4 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for BGLF4 (AA 386-417), (C-Term) antibody (ABIN1537299)

Target: BGLF4

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3734

Product Details

Binding Specificity: AA 386-417, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BGLF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 386-417 amino acids from the C-terminal region of human BGLF4.

Isotype: Ig Fraction

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References

Sun, Bristol, Iwahori, Hagemeier, Meng, Barlow, Fingeroth, Tarakanova, Kalejta, Kenney: "Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells." in: Journal of virology, Vol. 87, Issue 18, pp. 10126-38, (2013) (PubMed).

Meng, Hagemeier, Fingeroth, Gershburg, Pagano, Kenney: "The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production." in: Journal of virology, Vol. 84, Issue 9, pp. 4534-42, (2010) (PubMed).

Meng, Hagemeier, Kuny, Kalejta, Kenney: "Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutant." in: Journal of virology, Vol. 84, Issue 9, pp. 4524-33, (2010) (PubMed).

Target Details

Target: BGLF4

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Molecular Weight: 48351

Gene ID: 3783704

UniProt: P13288