FBXL19 antibody (C-Term)

Catalog No. ABIN1537454

There are 3+ publications for this product available. The Rabbit Polyclonal anti-FBXL19 antibody is suitable to detect FBXL19 in samples from Human. It has been validated for WB.

Quick Overview for FBXL19 antibody (C-Term) (ABIN1537454)

Target: FBXL19 (F-Box and Leucine-Rich Repeat Protein 19 (FBXL19))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL19 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB38770

Product Details anti-FBXL19 Antibody

Binding Specificity: AA 543-570, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FBXL19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 543-570 amino acids from the C-terminal region of human FBXL19.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: FBXL19 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

References for anti-FBXL19 antibody (ABIN1537454)

Dong, Zhao, Wei, Bowser, Khoo, Liu, Luketich, Pennathur, Ma, Zhao: "F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation." in: Molecular cancer, Vol. 13, pp. 76, (2014) (PubMed).

Wei, Mialki, Dong, Khoo, Mallampalli, Zhao, Zhao: "A new mechanism of RhoA ubiquitination and degradation: Roles of SCF(FBXL19) E3 ligase and Erk2." in: Biochimica et biophysica acta, (2013) (PubMed).

Zhao, Mialki, Wei, Coon, Zou, Chen, Mallampalli, Zhao: "SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 7, pp. 2611-9, (2013) (PubMed).

Target Details for FBXL19

Target: FBXL19 (F-Box and Leucine-Rich Repeat Protein 19 (FBXL19))

Alternative Name: FBXL19

Background: Members of the F-box protein family, such as FBXL19, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].

Molecular Weight: 75707

Gene ID: 54620

NCBI Accession: NP_001093254, NP_001269280

UniProt: Q6PCT2