PDZD3 antibody (AA 258-285)

Catalog No. ABIN1538201

The Rabbit Polyclonal anti-PDZD3 antibody is suitable to detect PDZD3 in samples from Human. It has been validated for WB.

Quick Overview for PDZD3 antibody (AA 258-285) (ABIN1538201)

Target: PDZD3 (PDZ Domain Containing 3 (PDZD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDZD3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB37960

Product Details anti-PDZD3 Antibody

Binding Specificity: AA 258-285

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: PDZD3 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for PDZD3

Target: PDZD3 (PDZ Domain Containing 3 (PDZD3))

Alternative Name: PDZD3

Background: Guanylyl cyclase C (GCC, or GUCY2C, MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR, MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).

Gene ID: 79849

NCBI Accession: NP_001161940, NP_079067

UniProt: Q86UT5